How To Make Cash By using deacetylase inhibitor Dinaciclib

The preliminary results were presented on the 2011 Annual Meeting on the American Society of Clinical Oncology.

Essentially the most frequently reported deacetylase inhibitor drug related adverse effects of any grade were fatigue, diarrhea, anorexia and rash. Pharmacokinetic analysis indicated that sorafenib had no effect on the disposition of tivantinib. Among 14 of 18 patients with evaluable responses, a best response of SD for 7?32 weeks was demonstrated. The majority of patients with SD had renal cell cancer or hepatocellular cancer. These results indicate that a combination of sorafenib and tivantinib is safe and may have therapeutic potential. This ongoing multicenter, phase Ib dose escalation trial is examining the safety and tolerability of tivantinib at doses of 120?360 mg twice daily across different schedules in combination with gemcitabine at 1000 mg/m2/ weekly 3 every 4 weeks.

Patients with locally advanced or metastatic colorectal cancer who received more than one prior line of chemotherapy, were KRAS wild type and had PARP Eastern Cooperative Oncology Group performance status less than 2 were included in this study. Patients were treated with irinotecan and cetuximab every 2 weeks along with escalating doses of tivantinib twice daily. Preliminary toxicity and efficacy data are available for nine patients. No DLTs were observed and grade 3/4 adverse events included neutropenia, fatigue and one case each of grade 3 leukopenia, acneiform rash, vomiting, diarrhea, anemia and syncope. In nine patients with evaluable responses, best responses included one complete response, 2 PRs, five SD and one progressive disease.

Interestingly, this study also demonstrated the potential antimetastatic activity of tivantinib. For intention deacetylase inhibitor to treat patients, median time to new metastatic lesions was increased from 3. 6 months in the erlotinib plus placebo arm to 7. 3 months in the tivantinib plus erlotinib arm.