The mean steady state exposure guidelines following multiple oral doses of CP 690,550 co given with single dose MTX were much like exposures following multiple dosing of CP 690,550 alone. The exposure parameters observed following multiple dosing of CP 690,550 alone are consistent with those seen previously in patients with RA. Neither total amounts of CP 690,550 excreted Aurora B inhibitor in urine nor renal clearance were aected with a single dose of MTX. In both treatment periods, CP 690,550 peak plasma concentration was reached within 0. 51 h following administration.
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